Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

Targeting of chemotherapeutics towards a tumor site by magnetic nanocarriers is considered promising in tumor-control. Magnetic nanoparticles are also for use infection-control as new means to prevent antimicrobial resistance from becoming the number one cause death year 2050. To this end, can either be loaded with an delivery vehicle or modified acquire intrinsic properties. used local generation heat kill infectious microorganisms. Although appealing tumor- and infection-control, injection blood circulation may yield reticuloendothelial uptake physical obstruction organs that reduced targeting efficiency. This prevented suitable surface modification. However, precise techniques direct target lacking. The problem aggravated due micrometer-size biofilms, opposed centimeter-sized tumors. review aims identify possibilities impossibilities infection-control. We first spatial resolution they achieve well surface-chemical modifications enhance their efficiency efficacy. It concluded problems encountered tumor-control using nanoparticles, neglected most studies on potential application Currently biofilm smart, self-adaptive pH-responsive, instance, seems easier than targeting. leads conclusion control micrometer-sized biofilms less initially expected. propulsion rather field traverse through infectious-biofilms create artificial channels enhanced antibiotic transport. identified more feasible, innovative distribution over depth biofilm.